http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111893121-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-136 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-532 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6851 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6851 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6886 |
| filingDate | 2020-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111893121-B |
| titleOfInvention | Circular RNA and application thereof |
| abstract | The invention discloses a circular RNA and application thereof, wherein the cDNA sequence of the circular RNA is shown as SEQ ID NO: 1, the structure of the circular RNA is SEQ ID NO: 1 is spliced after being transcribed to form an end-to-end circular structure. The invention detects the expression difference condition of the circDLC1 in the liver cancer tissue and the tissue beside the cancer through QPCR, finds that the expression of the circDLC1 in the liver cancer tissue is obviously lower than that of the tissue beside the cancer, shows that the circDLC1 can be used for liver cancer diagnosis, can confirm through migration and invasion experiments that the migration and invasion capacity of the liver cancer cell is obviously inhibited after the circDLC1 is over-expressed, shows that the circDLC1 can be used as a treatment target spot for diagnosis and treatment of hepatocellular carcinoma; by constructing a nude mouse subcutaneous tumor model, a nude mouse liver cancer in-situ model and a nude mouse late lung metastasis model, the circDLC1 overexpression is proved to have an inhibiting effect on the proliferation, invasion and metastasis of liver cancer cells in a nude mouse body. |
| priorityDate | 2020-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 154.