http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111893045-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2533-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2503-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-999 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-73 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-069 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5064 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M29-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M23-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M41-46 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 |
| filingDate | 2020-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111893045-B |
| titleOfInvention | In Vitro Model of Central Nervous System Intoxication and Method for Evaluating the Efficacy of Heavy Activators |
| abstract | The invention belongs to the field of medicine, and specifically relates to a method for establishing an in vitro model of central nervous system organophosphorus compound poisoning, comprising the following steps: (1) obtaining a transwell in vitro blood-brain barrier model; (2) adding a concentration of 0.065 to 0.20 mg/ml The acetylcholinesterase solution and the organophosphorus compound solution with a volume percentage concentration of 0.5× 10-8-10-3 were sequentially added to the lower pool of the transwell in vitro blood - brain barrier model at a volume ratio of (1-10):1, and left to stand for 1 to 10 minutes to obtain an in vitro model of central nervous system organophosphorus compound poisoning. The invention also relates to a method for evaluating the efficacy of the acetylcholinesterase reactivator in vitro. The in vitro model of the invention effectively simulates the poisoning of the organophosphorus compound in the central nervous system, and the evaluation method of the invention can accurately and rapidly evaluate the curative effect of the acetylcholinesterase heavy activator. |
| priorityDate | 2020-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 87.