http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111892612-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c189eedf29b8d6e547d5b386c2d46c33 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D499-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D507-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D499-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D507-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-46 |
| filingDate | 2020-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b04d1435165a701d1427ab58a9204d30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1964dad43aceecdc292796146846a26d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a93b53f7ddbf36d1ded9955f6879b82b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a81a73f7f70f37239528ec06942bc584 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a613693459107ad5561040afc1737658 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e7d56307ae208387ba1af430bcbf108 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_68d644bf3be45c5a12a484316bab76a5 |
| publicationDate | 2020-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111892612-A |
| titleOfInvention | A kind of intermediate isomerate for preparing cefavicin by using penicillin potassium salt as raw material and preparation method thereof |
| abstract | The invention discloses an intermediate isomer for preparing cefavicin by using penicillin potassium salt as a raw material and a preparation method thereof. Add the dehydrated reaction organic solvent to the reaction vessel, then add the intermediate oxide, adjust the temperature to 90-100°C, stir until the solution is clear, add trimethyl phosphite, adjust the vacuum, and control the reaction temperature to be 90-100°C , react until the reaction is complete, cool to below 30°C under nitrogen protection, add organic base to the reaction vessel, and react under nitrogen protection below 30°C to avoid light until the reaction is complete to obtain intermediate isomers. Compared with the existing steps, when the intermediate of the present invention is synthesized, it is prepared by a one-pot method, which reduces the difficulty of operation. Since the stability of the cephalosporin nucleus is poor, the present invention improves the selectivity of the reaction through strict control of the reaction conditions, and finally makes the reaction yield high and the product quality good. |
| priorityDate | 2020-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 75.