| abstract |
The invention belongs to the technical field of medicinal chemistry, and in particular relates to a new intermediate of palbociclib 4-(6-(8-cyclopentyl-5-methyl-7-oxo-6-(1-propoxyvinyl )-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl)-piperazinyl-1-carboxylate tert-butyl ester and crystal form and preparation method thereof. The process of the invention is simple in operation and post-treatment, the crystallization solvent is easy to recycle and the cost is low, the obtained intermediate is easy to crystallize, has good stability, good purity and high yield, and is more suitable for technological production. |