| abstract |
The invention discloses a sustained and controlled release preparation, a preparation method thereof and application thereof in preparing in-situ tumor immune combination treatment medicines, relating to the technical field of biomedical nano materials. The sustained and controlled release preparation takes liquid crystal gel as a carrier, and the liquid crystal gel is loaded with an immunogenicity inducer and an immunomodulator. The sustained and controlled release preparation can be prepared into a liquid crystal precursor by adopting a simple stirring and mixing method, and then an immunogenicity inducer and an immunomodulator are loaded. The invention co-loads the immunogenicity inducer and the immunomodulator in the in-situ slow-release liquid crystal gel, can form a semisolid gel in situ after intratumoral, peritumoral or postoperative intratumoral administration, slowly and slowly release the medicine, effectively regulates the tumor microenvironment, plays a role in inhibiting the growth, recurrence and metastasis of the tumor, simultaneously reduces the systemic toxic and side effects caused by the traditional administration way, and has potential application prospect in the in-situ local treatment of the tumor. |