Predicate |
Object |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-569 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J20-265 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-4291 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J20-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J20-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-02 |
filingDate |
2020-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2021-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate |
2021-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
CN-111875706-B |
titleOfInvention |
Single-domain antibody of anti-human IgE protein and application thereof |
abstract |
The invention relates to the field of blood purification, in particular to a single domain antibody of anti-human IgE protein and application thereof. The structural general formula of the amino acid sequence of the single domain antibody is as follows: MDVQLQESGGG-X 1 ‑LSC‑X 2 ‑GRFTIS‑X 3 -GQGTQVTVSS; wherein X 1 Is an amino acid sequence of 1-9 amino acids, X 2 Is an amino acid sequence of 1-43 amino acids, X 3 Is an amino acid sequence containing 1 to 38 amino acids. The invention screens the soluble single-domain antibody which can be expressed by pronucleus or eukaryon by the phage display technology, and has low production cost. The immunoadsorbent synthesized by coupling the obtained single-domain antibody to a solid phase carrier has high human IgE adsorption amount and good specificity; and the nonspecific adsorption of human IgG is low. The single domain antibody of the anti-human IgE protein provides a new choice for treating allergic diseases. |
priorityDate |
2020-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |