| abstract |
The invention discloses a compound containing an indazole heterocyclic skeleton and application thereof, belonging to the field of pharmaceutical chemistry. The compound containing indazole heterocyclic skeleton has good inhibitory activity on PDE4B, can be used as a PDE4B inhibitor, and is used for preparing medicaments for preventing or treating diseases related to PDE4B, including medicaments for treating inflammation-related diseases such as chronic obstructive pulmonary disease, asthma, dermatitis and psoriasis, and medicaments for treating central nervous diseases such as Alzheimer's disease, anxiety and cognition. |