| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1067a24fbb73ed3ff0c2a6a36ebe5a31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7f0b7004746ddc0695a034f58be3b07e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 |
| filingDate |
2020-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fec4a3ddda9605554619b4d84b6502e4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2eecc0bb1f5bbd8fc8502742ba51345b |
| publicationDate |
2020-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-111870696-A |
| titleOfInvention |
Application of mitophagy inhibitor in the preparation of drugs for improving the sensitivity of hepatoma cells to sorafenib |
| abstract |
The invention discloses an application of a mitophagy inhibitor in preparing a drug for improving the sensitivity of liver cancer cells to Sorafenib, and belongs to the technical field of biomedicine. This method restores the sensitivity of cells to sorafenib by inhibiting mitophagy at the drug or gene level. The invention can significantly enhance the sensitivity of hypoxia-induced sorafenib-resistant liver cancer cells to sorafenib, enhance the therapeutic effect of sorafenib, and provide a new idea for overcoming the targeted drug resistance of liver cancer. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113801935-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114369654-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113244378-A |
| priorityDate |
2020-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |