http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111870638-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K127-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2020-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111870638-B |
| titleOfInvention | Application of theabrownin in preparation of medicine for treating liver cancer |
| abstract | An application of theabrownin in preparing a medicament for treating liver cancer, which belongs to the technical field of theabrownin application. The method specifically comprises the following steps: the theabrownin can promote the apoptosis of hepatocellular carcinoma Huh7 cells by activating a JNK signal path and inhibit the growth of liver cancer transplantable tumors. The invention proves that the theabrownin has obvious antiproliferative and proapoptotic effects on Huh7 cells and has a dose-dependent effect through various experiments. Theabrownin promotes Huh7 cell apoptosis and inhibits growth of zebrafish liver cancer transplantable tumors by activating JNK signaling pathway. The inhibition rate of theabrownin on tumors can reach 48.1%. In addition, theabrownin regulates downstream apoptosis-related genes by activating P53 pathway PUMA, NOXA, Bax and Bcl-2 Etc. to promote apoptosis of P53 wild Sk-hep1 cells. |
| priorityDate | 2020-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 70.