| abstract |
The present invention relates to novel pyridone or pyrimidinone hydroxamic acid phosphates of formula (1) and borates of formula (2), their stereoisomers; and their use as LpxC inhibitors, and more particularly, its use for the treatment of bacterial infections; wherein Q is selected from the group consisting of -P(O)(OH) 2 , -P(O)(OH)(O - M + ), -P(O)(O - M + ) 2 , and -P( O)(O- ) 2M2+ ; M + is a pharmaceutically acceptable monovalent cation at each occurrence; and M2 + is a pharmaceutically acceptable divalent cation; X is CH or N; and Z as defined herein. |