| abstract |
The invention belongs to the field of medicinal chemistry, and relates to a novel pyridone derivative represented by formula (I) or its stereoisomer, pharmaceutically acceptable salt, solvate or crystal and its use in the preparation of prevention or treatment of influenza A or The application of drugs for viral infectious diseases such as influenza B, especially the application of PA subunit cap-dependent endonuclease inhibitor in the prevention or treatment of influenza A or/and influenza B viral infections. The compounds of the present invention have significant activity of inhibiting influenza endonuclease and influenza DNA, and can be used alone or in combination with neuraminidase inhibitors, nucleoside drugs, PB2 inhibitors, PB1 inhibitors, M2 inhibitors or other anti-influenza drugs The combined drug can significantly shorten the time of influenza infection and reduce the mortality rate, and has an excellent clinical application prospect. |