| abstract |
The invention discloses a puerarin anhydrous substance spherical crystal and a preparation method and application thereof, belonging to the technical field of medicines. By selecting a proper solvent system and controlling proper temperature and stirring speed, the puerarin anhydrous spherical crystal can be formed, the crystallization process is simple, convenient and quick, the obtained spherical product has round and smooth particles, the Carl index is about 10-18%, the angle of repose is 24-31 degrees, and the flowability and the compressibility are good. The anhydrous spherical crystal is different from the commercial puerarin monohydrate crystal in powder X-ray diffraction spectrogram, DSC spectrogram, TGA spectrogram and infrared spectrogram, and is a new solid form of puerarin. The invention has important practical value for the research of puerarin crystal form and the production and application of spherical crystal. |