| abstract |
The invention relates to the technical field of medicine, in particular to the application of pomegranate peel tannins in the preparation of medicines for inhibiting bacterial quorum sensing systems. The invention discloses the application of pomegranate peel tannin in the preparation of a drug for inhibiting bacterial quorum sensing system, the application in the preparation of a drug for inhibiting the secretion of bacterio aeruginosa, the application in the preparation of a drug for inhibiting the secretion of bacterial elastase, and the application in the preparation of a drug for inhibiting the growth of bacteria application in medicine. The experimental results show that pomegranate peel tannin can effectively inhibit the lasB signaling pathway and pqsA signaling pathway in Pseudomonas aeruginosa, thereby inhibiting the secretion of elastase and pyocyanin, and also inhibiting the growth of Pseudomonas aeruginosa. This further reduces bacterial virulence and pathogenicity, making it difficult for Pseudomonas aeruginosa to develop drug resistance. In addition, pomegranate peel tannin is a natural substance, and its toxicity and side effects are very low. Pomegranate peel tannin can be used alone or as an auxiliary therapeutic agent for antibiotics to achieve the purpose of preventing and treating bacterial infections. |