| abstract |
The invention provides the pharmaceutical use of small molecule inhibitors in the preparation of inhibiting the interaction between ornithine decarboxylase and ornithine decarboxylase anti-enzyme 1, as well as the application in the preparation of medicines for stabilizing the inactive dimer of ornithine decarboxylase . The small molecule inhibitor includes 6-[N'-(4-dimethylaminobenzyl)-hydrazino-[1,3,5]triazole-2,4-diamine, or 1- Butyl-N-(4-chlorophenyl)-1H-benzo[d]imidazol-2-amine, or 1,3-dimethyl-8-(2-thienyl)-3,7-dihydro Any one of -1H-purine-2,6-dione. |