| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6609344058456ca7611939c9dbb1b506 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-15043 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0097
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0034
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1896
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0002 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-867
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-10 |
| filingDate |
2020-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_771e2ae335468baffb22d1dbbf5b8211
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46eef6d6c2fbe2b0ce20d630a7cabcc1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eaee018c8a9a703ddce94ac32e299573
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_05f1ea41a2281fc85f1aa46ec501cb3f |
| publicationDate |
2020-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-111826401-A |
| titleOfInvention |
Application of OATP1B3 in the preparation of a magnetic resonance/near-infrared reporter for monitoring transplanted cells and/or their in vivo tracers |
| abstract |
The invention provides the application of OATP1B3 in the preparation of a magnetic resonance/near-infrared reporter for monitoring transplanted cells and/or in vivo tracking thereof, belonging to the technical field of molecular imaging. Using OATP1B3 as a reporter molecule, the proliferation or transplantation of living target cells or transplanted cells is indirectly reported through near-infrared or MRI dye uptake. OATP1B3-mediated ICE uptake has strong fluorescence output characteristics in the near-infrared band, can track cell migration, survival and migration, and shows bright contrast enhancement on T1-weighted MRI, OATP1B3 as a multimodal reporter tracking cell migration tracking Xenograft survival time. Accordingly, the present invention provides the use of OATP1B3 in the preparation of a magnetic resonance/near-infrared reporter for in vivo tracking and/or monitoring of transplanted cells. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111855729-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111855729-A |
| priorityDate |
2020-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |