http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111825815-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F2438-03 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5146 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F293-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-136 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F293-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-136 |
| filingDate | 2020-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111825815-B |
| titleOfInvention | Preparation method and application of stimuli-responsive degradable nanoparticles based on reactive block copolymer |
| abstract | The present invention relates to the preparation method and application of stimuli-responsive degradable nanoparticles based on reactive block copolymers, using polyethylene glycol-b-(2-vinyl-4,4-dimethylazlactone) (PEG‑b‑PVDMA) block copolymers (BCPs) serve as reaction platforms to prepare stimuli-responsive nanoparticles for loading and controlled release of molecular cargo. The microphase separation of PEG‑b‑PVDMA BCPs allows the construction of well-defined nanoparticles in aqueous solutions. The azlactone group in the repeating unit of PVDMA provides active sites for the hydrophilicity of BCPs and the functionalization of primary amines. The hydrophilicity of PEG‑b‑PVDMA BCPs induced reconstitution and degradation of self-assembled BCP nanoparticles. Functional primary amines can be combined with PEG-b-PVDMA BCPs to generate Azo-containing BCPs and pyr BCPs. The nanoparticles of the present invention can bind molecular cargoes and release them upon external stimuli, making azlactone-containing BCPs an attractive platform for the development of control delivery vehicles. |
| priorityDate | 2020-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.