| abstract |
The present invention provides a composite cryogel, a preparation method and application thereof. The composite cryogel comprises a zwitterion cryogel and nano-zinc oxide dispersed in the zwitterion cryogel. The glue is formed by self-crosslinking of zwitterionic monomers below 0°C. In the present invention, the zwitterionic monomer is used as the main material, and nano-zinc oxide particles are added, and the zwitterionic monomer undergoes self-crosslinking at low temperature, so that the nano-zinc oxide is wrapped inside the cryogel. At room temperature, the ice crystals formed by water in the gel melted so that the cryogel formed pores of uniform size, which was conducive to cell adhesion and material transport, and at the same time, it was able to stably release the nano-zinc oxide particles, which were further in osteoblasts. Zinc ions are dissolved in the acidic vesicles to release zinc ions, and the properties of zinc ions to promote the differentiation and proliferation of osteoblasts are used to play a pro-osteogenic function. |