| abstract |
The invention discloses a cyclic compound and its application. A kind of cyclic compound as shown in formula I of the present invention or a pharmaceutically acceptable salt thereof; wherein, X is -CH 2 - or -O-; Y is -CR 1 R 2 -; R 1 and R 2 are independent Z is -CH 2 - or -O-; n is 1 or 2; R is independently halogen, C 1 ~C 4 alkyl, or, halogen-substituted C 1 ~C 4 alkane Oxygen. The cyclic compound has better NaV1.8 blocking activity. |