| abstract |
The invention provides a cinnamic acid derivative and an inverse preparation method thereof. Triazole was added to 50 ml of solvent, 0.2 mmol of catalyst was slowly added dropwise, and the reaction was carried out at room temperature for 2 h. After concentration, it was separated with a silica gel column, and then hydrolyzed under the action of a strong base, and then acidified by adding acid to adjust the pH value; then 1 mmol D was added. -Phenylalanine methyl ester hydrochloride, 1.2mmol condensation reagent and 1.2mmol HOAT, 30ml solvent, 0.1mmol catalyst, react at room temperature for 2h, concentrate and purify with silica gel column, then hydrolyze under the action of strong base, add acid Acidification was performed to adjust the pH. The compound of the present invention has excellent activity of inhibiting neuroinflammation, and can be used in the preparation of neuroinflammation inhibitor and medicament for treating senile dementia. |