| abstract |
The present application belongs to the technical field of small-molecule photothermal materials, and in particular relates to a thiazole orange derivative and its preparation and application. The application provides a thiazole orange derivative with the structure of formula I; wherein, n=1, 2 or 3; X is I, Br or Cl; R 1 is a fatty amide group, a fatty carboxyl group or a fatty alkyl group; R 2 is triphenylphosphine or triphenylamine. The present application also provides a method for preparing a thiazole orange derivative, comprising the following steps: reacting the compound of the formula IX structure with the compound of the formula VII structure to obtain the compound of the formula I structure; wherein, n=1, 2 or 3; The R 2 is triphenylphosphine or triphenylamine; the Y is I, Br or Cl; the X is I, Br or Cl; the R 1 is a fatty amide group, a fatty carboxyl group or a fatty alkyl group. The application of the thiazole orange derivatives disclosed in the present application in the preparation of targeted photothermal therapy drugs for tumors or targeted photoacoustic imaging signal drugs. |