http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111793027-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C63-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C63-06 |
| filingDate | 2020-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111793027-B |
| titleOfInvention | Eutectic of lenvatinib and benzoic acid and preparation method thereof |
| abstract | The invention discloses a Levatinib and benzoic acid eutectic crystal and a preparation method thereof. The molar ratio of lenvatinib to benzoic acid in the eutectic is 1: 1, and the eutectic X-ray powder diffraction pattern has characteristic peaks at 2theta values of 6.4 +/-0.2 degrees, 7.4 +/-0.2 degrees, 12.5 +/-0.2 degrees, 14.7 +/-0.2 degrees, 16.7 +/-0.2 degrees, 17.7 +/-0.2 degrees and 23.8 +/-0.2 degrees. The preparation method of the eutectic crystal provided by the invention has the advantages of simple process, easy control of the crystallization process, good reproducibility and suitability for industrial production. Compared with lenvatinib mesylate, the eutectic has lower hygroscopicity, faster dissolution rate and larger apparent solubility, and provides a material basis for improving the stability and oral absorption efficiency of lenvatinib and reducing the process threshold and cost of a preparation. |
| priorityDate | 2020-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 63.