| abstract |
The present invention relates to the use of triene oleanolic acid methyl ester for preparing a drug for preventing and treating viral hepatitis B. Specifically, the present invention provides oleanane 2,11,13(18)-triene-28-carboxylic acid The application of methyl ester in the preparation of medicine against hepatitis B virus infection. The compound has obvious activity of inhibiting the HBsAg and HBeAg secreted by HepG2.2.15 cells, and the intensity of inhibiting the secretion of HBsAg and HBeAg at a concentration of 100 μg/ml on the 8th day is higher than that of the positive drugs α-interferon and lamivudine , the inhibition rate of HBV-DNA replication at this concentration is also higher than that of α-interferon. The above shows that the triene oleanolic acid methyl ester can be expected to be used for the preparation of non-nucleoside drugs for the treatment of hepatitis B virus infection. , the purpose of the HBeAg inhibitor; and the preparation method has simple steps, low cost, wide source of raw materials, and easy industrial production. |