| abstract |
The present invention relates to the use of anhydroalanone oleanolic acid for preparing antiviral drugs, in particular, the present invention provides 3-carbonyl oleanane-12-ene-28-acid in the preparation and prevention of hepatitis B virus infection The use of medicines for diseases. The compound has significant activity of inhibiting the secretion of HBsAg and HBeAg from HepG2.2.15 cells. At the concentration of 100 μg/ml on the 8th day, the intensity of inhibiting the secretion of HBsAg and HBeAg is 67.1% and 83.1%, respectively. At this concentration, it inhibits HBV ‑DNA replication even showed an inhibition rate of over 96%. The above shows that the anhydroalkenone oleanolic acid can be expected to be used for the preparation of non-nucleoside drugs for the treatment of hepatitis B virus infection. The application of the HBeAg inhibitor; and the preparation method has simple steps, low cost, wide source of raw materials, and easy industrial production. |