abstract |
The present invention provides novel cytotoxic compounds and cytotoxic conjugates comprising these cytotoxic compounds and cell binding agents. More specifically, the present invention relates to novel Tylanstatin A analogs useful as cytotoxic small molecule toxins in antibody-drug conjugates (ADCs). The present invention also relates to compositions comprising these cytotoxic compounds and ADCs, and methods of using these toxins and ADCs to treat pathological conditions, including cancer. |