http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111785330-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6c6d22af4bf4e1b2205a929549da46d3 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B40-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5038 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16H20-60 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B40-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16H20-60 |
| filingDate | 2020-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94b067cf19710cd598c7d05fe66c6b06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5f16e78c15e5ca36950b03d94be2014 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25d117f7b3484a2092cdbab7fbb4b062 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ddca9be7e530fe7d7552fc7f65fa3dbe |
| publicationDate | 2020-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111785330-A |
| titleOfInvention | Screening method of anti-obesity active compound |
| abstract | The invention provides a screening method of an anti-obesity active compound, which comprises the following steps: firstly, constructing a lipid raft representative system based on the main components and content theory of the 3T3-L1 preadipocyte membrane lipid raft, and carrying out non-limiting molecular dynamics balance on the lipid raft system through molecular dynamics software; IC summarizing different structural polyphenols inhibiting preadipocyte differentiation 50 Values and polyphenol molecular structure parameters and data on the effect on lipid raft structure; establishment of differently structured polyphenols IC for inhibition of preadipocyte differentiation Using multivariate statistical methods 50 Searching a key evaluation index according to a theoretical relation between the value and the influence of the polyphenol with different structures on the lipid raft; finally, based on key evaluation indexes, different active compounds are classified through clustering analysis and verified through experiments. The screening method of the invention has low cost and strong stability,the screening result is reliable, and the molecular dynamics, the multivariate statistical method and the like are matched, so that convenience is provided for efficiently and quickly searching the anti-obesity active compound. |
| priorityDate | 2020-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 122.