| abstract |
The application provides a preparation method of moxifloxacin hydrochloride chelate, which belongs to the technical field of preparation of heterocyclic compounds. Keep the excess acetic acid, add trimethyl borate to the acetic acid, and react at 110-120 ° C; after the reaction is completed, lower the temperature and add the gating cyclic ester, and then heat up to 110-120 ° C after the addition, and continue the reaction; After the reaction was completed, the solvent was recovered to dryness to obtain a chelate compound. It has the advantages of simple process, economical environmental protection and high product purity. |