http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111777615-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0036 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0071 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2020-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111777615-B |
| titleOfInvention | Photodynamic therapy probe for detecting cyclooxygenase 2 and preparation thereof |
| abstract | The invention discloses a photodynamic therapy probe for detecting cyclooxygenase 2 and a preparation method thereof, wherein the structure of a probe compound is shown as a formula I. The prodrug molecule links the potent inhibitor of the cancer marker cyclooxygenase 2 indomethacin, utilizes flexible butane to a two-photon naphthamide fluorophore, and incorporates the Ce6 photosensitizer for photodynamic therapy. The probe has no obvious fluorescence in a buffer solution and normal cells, and the fluorescence and singlet oxygen quantum yield is increased dramatically in a solution for over-expressing cyclooxygenase 2 and cancer cells, so that the fluorescence imaging synergistic photodynamic therapy is realized. The probe has the advantages of having molecular targeting effect and photodynamic curative effect, and being an effective tool for identifying the tumor and generating singlet oxygen to kill the tumor under the excitation of light. |
| priorityDate | 2020-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 62.