| abstract |
The invention belongs to the field of medicine, and discloses a composition containing aloe vera extract and application thereof. Use can increase DNA damage in cancer cells, up-regulate γH2AX protein level, block cell cycle in S phase, induce cell apoptosis and inhibit WNT/β-catenin signaling pathway, both synergistically enhance the cytotoxic activity of cancer cells , in order to achieve anti-cancer effect. It can be used in the preparation of anticancer drugs, WNT/β-catenin pathway inhibitors, and WNT/β-catenin pathway semaphorin inactivators. |