| abstract |
The invention belongs to the field of medicine, and discloses a preparation method of a buflomedil hydrochloride sustained-release preparation, comprising the following steps: 1) respectively pulverizing buflomedil hydrochloride, hypromellose (HPMC) and acrylic resin, 100 mesh sieve, standby, the mass ratio of buflomedil hydrochloride, hypromellose and acrylic resin is 10:3:5; 2) buflomedil hydrochloride, hypromellose after pulverizing step 1), hypromellose and acrylic resin, pass through an 80-mesh sieve and mix evenly to obtain a mixture A; 3) add a binder to the mixture A obtained in step 2) to prepare a soft material, and pass through a 20-mesh sieve to prepare granules. The process of the buflodil hydrochloride sustained-release preparation of this scheme is simple, the conditions are mild, the control is easy, and it is suitable for mass production, and the drug release of the prepared buflodil hydrochloride sustained-release preparation tends to be slow and stable, and the sustained-release function is better. Good, the drying temperature of the material is low, the prepared drug-carrying preparation is uniform in size, and is easy for industrial production. |