| abstract |
The invention belongs to the field of medicinal chemistry, and relates to a series of natural products of Cordyceps secondary metabolite Annulatins and a preparation method and application thereof. Through experiments, a total synthesis route was designed and established, using commercially available raw materials as substrates, and through mild reactions, the preparation of Annulatins series of natural products was completed. The Annulatins series natural products designed by the invention have been tested for anti-diabetic vascular complication activity in vitro, and the results show that they have a protective effect on vascular endothelial cells induced by high glucose, which is beneficial to the clinical prevention and treatment of diabetic vascular complications. It has the following general structural formula: |