http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111763157-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-16 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 |
| filingDate | 2020-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111763157-B |
| titleOfInvention | Chiral amino compound, preparation method and application thereof, and preparation method for preparing edoxaban intermediate from chiral amino compound |
| abstract | The invention provides a chiral amino compound, a preparation method and application thereof, and a preparation method for preparing an edoxaban intermediate from the chiral amino compound. The structure of the chiral amino compound is shown as a formula (III); the structure of the edoxaban intermediate prepared by the formula (III) is shown in the formula (I); wherein R is 1 And R 2 Independently a nitrogen protecting group or hydrogen; r is C 1～6 Alkoxy, N-dimethylamino, N-methylamino or benzylamino. The compound of the formula (III) can be prepared in a large scale and with high optical purity by only one-step reaction, a chiral resolution process is not needed, the preparation process is simple and efficient, and the cost is low; the compound of formula (III) is used as a raw material, and the edoxaban intermediate of formula (I) can be prepared through one-step reaction, expensive (S) -3-cyclohexene-1-formic acid is not needed as an initial raw material, chiral resolution is not needed, the route is short, the use of sodium azide can be effectively avoided, the reaction conditions are mild, the yield is high, and the method is suitable for large-scale industrial production. |
| priorityDate | 2020-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 78.