http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111748619-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aeb5f2e384698de368d52acbd33a2d60 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-485 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6886 |
| filingDate | 2019-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39a2aec88e9363a71f493fbe7aa0c687 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2fa1be29e0053a23c2d470a004548222 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e45593d330698ae8f6327a0431d39b32 |
| publicationDate | 2020-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111748619-A |
| titleOfInvention | Inhibitor or inhibitor system for inhibiting tumor cell GSK-3 beta double targets and screening method thereof |
| abstract | The invention relates to an inhibitor or an inhibitor system for generating a cancer inhibition effect by targeted inhibition of GSK-3 beta double-target activity in tumor cells and a screening method thereof. The invention discloses GSK-3 beta Y216 and GSK-3 beta Ser9 double-target activity for inhibiting (blocking/inactivating) GSK-3 beta in tumor cells; or an inhibitor system which inhibits the activity of the double targets by mutating the gene codes of the double targets or interfering the gene transcription and translation, thereby generating the cancer inhibition effect, and a screening method thereof. The cancer inhibition effect of the inhibition (blocking/inactivation) double targets is obviously superior to the cancer inhibition effect of any single target. The invention provides a new method, a new idea and a new strategy for screening or developing a new targeting drug for clinical targeted therapy of tumors (preferably liver cancer and digestive system tumors); provides a new double-target combination and a new medicine for clinically treating tumors. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112426532-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022121356-A1 |
| priorityDate | 2019-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 319.