| abstract |
The present disclosure generally relates to Fc polypeptide dimers that contain non-native transferrin receptor (TfR) binding sites that do not substantially deplete reticulocytes in vivo, but remain bound to Fcg receptors (FcgR). The present disclosure also relates to an Fc polypeptide dimer containing a non-native site on one of the Fc polypeptides that specifically binds TfR; The modification or modifications of the Fc polypeptide that reduce FcgR binding when bound to TfR, wherein the other Fc polypeptide does not contain a TfR binding site, but retains FcgR binding. |