| abstract |
The present disclosure relates to methods and compositions for inducing an immune response in a subject comprising co-administering to the subject an RNA encoding a peptide or protein for vaccination and an IL encoding an IL linked to a pharmacokinetic modifying group RNA of -2 and/or RNA encoding IL-7 linked to a pharmacokinetic modification group. The vaccine is particularly effective if an immune checkpoint inhibitor, such as an anti-PD-L1 antibody, is additionally administered. The present disclosure also relates to methods comprising target-specific delivery of cytokines to target organs or tissues. |