| abstract |
The present invention relates to a solid oral dosage form comprising 6 mg of d6-tetrabenazine and about 5% to about 30% by weight of the dosage form of a polymer, the polymer being poly(ethylene oxide) alkane) polymers, Colidan polymers, hydroxypropyl methylcellulose polymers, hydroxypropyl cellulose polymers, carbopol polymers, or combinations thereof, wherein if the oral dosage form is orally administered in a fed state People, then its administration result is: the AUC inf of the total combined amount of deuterated dihydrotetrabenazine in the plasma of about 132hr*ng/mL; Cmax of tetrabenazine. The present invention also relates to pharmaceutical compositions involving crystalline forms, including such crystalline forms, and methods of treatment for administering the same. The technical scheme of the present invention makes the pharmacokinetic parameters of tetrabenazine excellent. |