| abstract |
The invention discloses the application of copper gluconate in the preparation of a medicament for preventing or treating novel coronavirus infection. The copper gluconate has a molecular formula of Cu(C 6 H 11 O 7 ) 2 and can inhibit the activity of the novel coronavirus PLpro protein. The inhibition type of copper gluconate was competitive inhibition, and the inhibition constant K i value was 55.3 nmo/L. In the present invention, it has been proved that the copper gluconate can be used to prepare medicines for preventing or treating novel coronavirus infection. When in use, copper gluconate can be used alone, or compounded with medicines, compounds and carriers to form oral preparations and injections. , paints, lotions, aerosols, oil preparations or transdermal patches and other forms of pharmaceutical compositions. The present invention provides new compounds and new ideas for the prevention or treatment of novel coronavirus. |