http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111718708-B

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filingDate 2019-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2021-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-111718708-B
titleOfInvention Relay type nanometer rare earth up-conversion luminescent material and relay type protease activity detection method
abstract A relay type nanometer rare earth up-conversion luminescent material and a relay type protease activity detection method belong to the field of protein detection. The method is mainly realized by constructing a nano rare earth up-conversion luminescent probe capable of carrying out relay type energy transfer, specifically, nano rare earth up-conversion luminescent particles are used as a core, a relay layer dye capable of absorbing light emitted by the up-conversion nano probe is directly connected to the surface of the nano particles, and a polypeptide substrate capable of forming a resonance energy transfer group with the relay layer dye is modified at the tail end. Under the irradiation of near infrared exciting light, protease capable of reacting with polypeptide substrate is added to detect the protease activity. The protease detection method has high detection sensitivity and universality and has certain clinical application value.
priorityDate 2019-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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