| abstract |
The invention belongs to the field of chemical medicine, in particular to a hyperuricemia pharmaceutical composition and use thereof, including a polyacetylene compound having a structure as shown in formula (I) and pharmaceutically acceptable salts, esters and prodrugs thereof , a solvate, a polymorph, a hydrate or a derivative combined with a drug for hyperuricemia in the preparation of a combined drug for the treatment of hyperuricemia, and a hyperuricemia drug composition is also provided, comprising the above compound, and one of benzbromarone or lesinard. The hyperuricemia pharmaceutical composition can have a uric acid-lowering effect equivalent to or even better than the hyperuricemia drugs in the prior art, but can significantly reduce the toxic and side effects of the hyperuricemia drugs, improve safety, and can be used. For the treatment of hyperuricemia and hyperuricemia-induced gout or gout complications. |