http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111705099-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 |
| filingDate | 2020-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111705099-B |
| titleOfInvention | Preparation method of (S) -1- (3, 5-dichloropyridine-4-substituted) ethanol |
| abstract | The invention discloses a preparation method of (S) -1- (3, 5-dichloropyridine-4-substituted) ethanol. The substrate 1- (3, 5-dichloropyridine-4-yl) ethanone is subjected to asymmetric reduction in a buffer solution with the pH value of 6.0-8.0 in the presence of a ketone reductase and coenzyme regeneration system at the temperature of 20-37 ℃ to generate (S) -1- (3, 5-dichloropyridine-4-substituted) ethanol. The method effectively improves the preparation method of the (S) -1- (3, 5-dichloropyridine-4-substituted) ethanol by adding cheap and easily-obtained auxiliary materials, and has lower cost and higher yield and optical purity compared with the existing chemical asymmetric synthesis method. |
| priorityDate | 2020-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.