| abstract |
The invention discloses an aryl spiro SHP2 inhibitor compound, a preparation method and application thereof. In particular to a nitrogenous aryl spiro-compound shown as a general formula I, or pharmaceutically acceptable salt thereof, or enantiomer, diastereoisomer, tautomer, solvate, polymorph or prodrug thereof, a preparation method and pharmaceutical application thereof, wherein the definition of each group is described in the specification. |