http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111704528-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-584 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C29-145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C41-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C33-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C33-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C41-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C29-145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C33-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C43-178 |
| filingDate | 2020-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111704528-B |
| titleOfInvention | A kind of asymmetric synthesis method of chiral tetraol sugar alcohol compound |
| abstract | 1,2,3,4-Tetraol (C4 sugar alcohol) is a compound with four consecutive adjacent chiral hydroxyl groups, which has extremely high application value. The present invention provides a method for preparing chiral 1,2,3,4-tetraol compounds. The method is to carry out an asymmetric catalytic hydrogenation reaction between compound I and hydrogen through the action of an iridium complex catalyst of ferrocene type PNN type, PNO type tridentate ligands and a base in an organic solvent, through a dynamic kinetic mechanism. It can rapidly and efficiently construct 1,2,3,4-tetraols containing four consecutive chiral centers with high atom economy. The enantioselectivity of the product prepared by the method of the present invention is very high, the dr value can be up to >99:<1, the stereoselectivity, and the ee value is up to 99.9%. The substrate used in the present invention is easy to prepare, and the reaction conditions are mild, and the post-processing operation is convenient and concise, that is, the target compound can be obtained in high yield and high enantioselectivity, and the substrate is suitable for a wide range. |
| priorityDate | 2020-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 86.