http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111700881-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5169 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5123 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-22 |
| filingDate | 2020-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111700881-B |
| titleOfInvention | Wnt protein/ZIF-8 nano complex, preparation method and application thereof |
| abstract | The invention relates to the technical field of medicine preparation, in particular to a Wnt protein \ ZIF-8 nano complex, a preparation method and application thereof. The nano complex comprises a ZIF-8 zeolite imidazolate framework, and Wnt protein is loaded on the ZIF-8 zeolite imidazolate framework. According to the invention, the ZIF-8 is used for wrapping the Wnt protein, so that the disintegration rate of the ZIF-8 can be effectively slowed down, the release speed of zinc ions is slowed down, and the dosage of the ZIF-8 can be increased. Meanwhile, the ZIF-8 wraps the Wnt protein, so that the stability of the Wnt protein is improved, the Wnt protein is not easy to inactivate in a body fluid environment or in the processes of preparation, transportation and the like, and the physiological activity is improved. Meanwhile, the combination of the ZIF-8 and the Wnt protein has good effect of promoting osteogenesis, and the application range of the Wnt protein/ZIF-8 nano complex is expanded. |
| priorityDate | 2020-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 59.