http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111686127-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-243 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1818 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-26 |
| filingDate | 2020-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111686127-B |
| titleOfInvention | Application of zinc-iron nano material in degradation of mutant p53 protein |
| abstract | The invention discloses an application of a zinc-iron nano material in degradation of mutant p53 protein. The invention effectively degrades mutant p53 protein by regulating different zinc-iron ratios through an engineering means for the first time, realizes the diagnosis and treatment of p53 drug-resistant tumor by using the degradation mutant p53 in combination with chemotherapeutic drug therapy and nuclear magnetic resonance imaging, provides better reference for accurate therapy and surgical navigation, and provides a new strategy for the nano material to treat the mutant p53 tumor. The invention also finds that an enzyme inhibitor, E1 ubiquitin activating enzyme, an endocytosis inhibitor, TPEN, an antioxidant, an oxidase inhibitor and the like can inhibit the zinc-iron nano material from degrading the mutant p53 protein, and finds that the zinc-iron nano material can be used for removing the mutant p53 protein and effectively increasing the tumor killing effect of the chemotherapeutic drug cisplatin, so that the zinc-iron nano material can be used as a chemotherapeutic drug sensitizer or used in the anti-tumor aspect together with the chemotherapeutic drug. |
| priorityDate | 2020-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 202.