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filingDate 2020-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2022-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-111686077-B
titleOfInvention Aminoevodiamine polymer micelle and its preparation method and application
abstract The invention discloses amino evodiamine polymer micelles and a preparation method and application thereof. A 2-nitroevodiamine derivative is prepared from a carboline compound and N-methyl-7-nitrosatinic anhydride. The aminoevodiamine derivative is reduced to obtain aminoevodiamine derivative, and the polymer is reacted with aminoevodiamine to prepare aminoevodiamine polymer conjugate; then the aminoevodiamine polymer conjugate is self-assembled to obtain aminoevodiamine polymer conjugate To improve the water solubility and bioavailability of drugs, combine drugs with nanotechnology, and develop nano-drug loading systems for drug delivery. Nano-drugs can be passively targeted and enriched in tumor tissues through the EPR effect.
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