| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P39-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1025
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1029
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-45
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-45 |
| filingDate |
2020-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2022-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2022-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-111670048-B |
| titleOfInvention |
Method of enhancing anti-apoptotic pathways to prevent DOX toxicity |
| abstract |
A method of promoting an anti-apoptotic pathway in a mammalian cell by enhancing acetylation of the transcription factor GATA4, comprising: contacting said mammalian cell with an agent effective to increase acetylation of GATA 4. The agent was used to enhance acetylation of lysine residues 328 and 330 (K328/330) of the zinc finger region of GATA4 at its carboxy terminus. A method of inhibiting the deacetylase activity of SIRT6 in a mammalian cell, comprising: contacting a mammalian cell with an agent that is a peptide segment comprising the amino acid sequence represented by SEQ ID NO. 2, or an analog thereof, in an amount effective to inhibit the deacetylase activity of SIRT 6. |
| priorityDate |
2020-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |