| abstract |
The present invention provides a pyrazolopyrimidine-containing hydroxamic acid derivative and a preparation method and application thereof. The pyrazolopyrimidine-containing hydroxamic acid derivative has the structure shown in formula I: Wherein, X is selected from oxygen, amido and methylene; Y is selected from methine, substituted methine and nitrogen; Z is selected from methylene, benzyl, piperidinyl, pyridyl, pyrrolidinyl, pyrimidine base, imidazolyl and oxadiazolyl; piperidinyl is or The carbon end of piperidinyl is connected to the nitrogen end of pyrazole; R is selected from hydrogen, halogen, nitro, amino, substituted amino, cyano, methyl, methoxy and trifluoromethyl; n is 0-7 Any integer; when X is oxygen, Y is methine, and Z is When R is H, n is not 1. The compound of formula I has BTK and/or HDAC inhibitory activity, and has a good growth inhibitory effect on lymphoma, especially mantle cell lymphoma. |