http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111662233-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f63840112d93dd1f1a98ffa572538c45 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-90 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-90 |
| filingDate | 2020-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3fbc10dbc525eefeb3b31b3514e8f8a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01e49943e45448782cdba6461e3b2eed |
| publicationDate | 2020-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111662233-A |
| titleOfInvention | A kind of method for one-step synthesis of 4-chloro-1H-imidazole-2-carboxylic acid ethyl ester |
| abstract | The invention belongs to a pharmaceutical intermediate, and in particular relates to a method for synthesizing ethyl 4-chloro-1H-imidazole-2-carboxylate by one-step method. The present invention provides a method for synthesizing ethyl 4-chloro-1H-imidazole-2-carboxylate for the first time, and provides a synthetic route for the method for synthesizing ethyl 4-chloro-1H-imidazole-2-carboxylate. The route is short, the design is reasonable, the operation is simple, and the control is easy; the present invention uses compound A (1H-imidazole-2-ethyl carboxylate) as a raw material, and under the environment of low temperature and organic acid, through the organic acid to N-chlorine The succinimide molecule provides a better polarization environment, and at the same time improves the electrophilic activity of the substrate, promotes the reaction, reduces the generation of by-products, and improves the yield and purity of the product. |
| priorityDate | 2020-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.