http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111647038-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1077 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-33396 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-33389 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-333 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 |
| filingDate | 2020-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111647038-B |
| titleOfInvention | Hypoxia-responsive chemically modified protein and preparation method and application thereof |
| abstract | The invention discloses a hypoxic responsive chemical modified protein and a preparation method and application thereof.A preparation method comprises the steps of mixing activated monomethoxy polyethylene glycol and hydroxyazobenzene in the presence of alkali and a catalyst, heating and stirring for reaction to obtain hydroxyazobenzene of monomethoxy polyethylene glycol; then, reacting hydroxyazobenzene of monomethoxy polyethylene glycol with p-nitrophenyl chloroformate to obtain an hypoxic-responsive protein modified polymer; and under the alkaline condition, reacting the hypoxia-responsive protein modified polymer with the protein to obtain the hypoxia-responsive chemically modified protein. The hypoxia-responsive chemically modified protein prepared by the invention has excellent water solubility, does not change the secondary structure of the protein, and does not influence the performance of the protein after dissociation. |
| priorityDate | 2020-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.