http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111646958-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D303-36 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 |
| filingDate | 2020-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111646958-B |
| titleOfInvention | A kind of preparation method of carfilzomib |
| abstract | The present invention relates to a preparation method of carfilzomib, which takes the compound of formula I as an intermediate, and after deprotection, reacts with the compound of formula IV to prepare carfilzomib. The preparation of the compound of formula I includes the following steps: using hydrogen peroxide as an oxidant to prepare a carfilzomib intermediate, that is, the compound of formula I, by selective epoxidation with a chiral organic catalyst. The preparation method of the invention has simple reaction conditions, simple and convenient operation, good asymmetric selectivity, good yield and high purity, and is suitable for industrial production. |
| priorityDate | 2020-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.