http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111646940-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6967bba8150e0b546153ebb0fbc0eec9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-54 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-54 |
| filingDate | 2019-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_386bd4179c5cba46f543bd360893ef2f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_585205b5fd61e6bd9b02ad671c534a2a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe138d6206b778f4cc85ccf737125c75 |
| publicationDate | 2020-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111646940-A |
| titleOfInvention | Preparation method of bosutinib intermediate |
| abstract | The invention provides a synthesis method of a bosutinib intermediate. The method comprises the following steps: a: and (3) carrying out temperature-controlled reflux reaction on the compound 1 and the compound 2 in the presence of a solvent A, after the reaction is finished, concentrating the reaction liquid under reduced pressure until the reaction liquid is dried, and recrystallizing the obtained solid through a solution B to obtain an intermediate 1'. B: and adding the intermediate 1' into a solvent C, performing temperature-controlled cyclization reaction, cooling the reaction liquid to room temperature after the reaction is finished, adding a solvent D, and completely crystallizing to obtain the target product, namely the compound shown in the formula I. Compared with the prior art, the 7- (4-methylpiperazin-1-yl) propoxy-6-methoxy-4-oxo-1, 4-dihydro-3-quinolinecarbonitrile provided by the invention is a key intermediate for synthesizing the bosutinib. The bosutinib can be obtained by utilizing the intermediate only through two simple reactions in the follow-up process, so that long-time backflow is avoided, the reaction time is effectively shortened, and the purity of the obtained product is higher. |
| priorityDate | 2019-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 112.